منابع مشابه
Oxidative stress and disuse muscle atrophy.
Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-generating capacity. This disuse-induced muscle atrophy results from both increased proteolysis and decreased protein synthesis. Investigations of the cell signaling pathways that regulate disuse muscle atrophy have increased our understanding of this complex process. Emerging evidence implicates oxidative ...
متن کاملRedox homeostasis, oxidative stress and disuse muscle atrophy.
A pivotal role has been ascribed to oxidative stress in determining the imbalance between protein synthesis and degradation leading to muscle atrophy in many pathological conditions and in disuse. However, a large variability in disuse-induced alteration of redox homeostasis through muscles, models and species emerges from the literature. Whereas the causal role of oxidative stress appears well...
متن کاملMechanisms of disuse muscle atrophy: role of oxidative stress.
Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will addr...
متن کاملInvited Review HIGHLIGHTED TOPIC Free Radical Biology in Skeletal Muscle Oxidative stress and disuse muscle atrophy
Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol 102: 2389–2397, 2007; doi:10.1152/japplphysiol.01202.2006.—Skeletal muscle inactivity is associated with a loss of muscle protein and reduced forcegenerating capacity. This disuse-induced muscle atrophy results from both increased proteolysis and decreased protein synthesis. Investigations of the cell ...
متن کاملMuscle Deconditioning and Disuse Atrophy
Lack of physical activity can cause a muscle to atrophy. Muscle deconditioning may become apparent within days to weeks of decreased physical activity. For example, we have all known individuals who were physically fit during their high school days and then became less active over time. The cessation of regular activity causes the muscles to decrease in size, but contrary to what some people sa...
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ژورنال
عنوان ژورنال: Current Opinion in Clinical Nutrition and Metabolic Care
سال: 2012
ISSN: 1363-1950
DOI: 10.1097/mco.0b013e328352b4c2